1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University
theiz 23.10.2026

Light-sheet Microscope

 UltraMicroscope Blaze: high-resolution 3D imaging of whole organs and biological samples

The UltraMicroscope Blaze is a state-of-the-art light-sheet microscope designed for rapid 2D and 3D imaging of whole organs, tissues and other large biological samples. It enables imaging in up to seven fluorescence channels, with excitation ranging from the violet part of the spectrum to the near-infrared region. Samples up to 29 mm in size can be imaged in a single frame, whilst at the highest optical resolution it can capture details as small as 0.5 µm.

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Our microscope is already waiting for your ideas.

Technical specifications

Lenses and their theoretical resolution:
1.1×(NA 0.1)4,8 µm
4×(NA 0.35)1,3 µm
12×(NA 0.53)0,5 µm
Fluorescent filters:
ex: 405/30 nm em: 460/40 nm
ex: 470/30 nm em: 525/50 nm
ex: 500/20 nm em: 535/30 nm
ex: 560/40 nm em: 595/40 nm
ex: 630/30 nm em: 680/30 nm
ex: 710/75 nm em: 810/90 nm
ex: 785/25 nm em: 805LP nm

Aqueous and organic solutions with RI 1,33 - 1,56
Frame rate 100 fps

Some of the many applications

Neuroscience
  • Neuroanatomy of the whole brain
  • Development of the nervous system
  • Neurodegenerative diseases
Oncology and cancer research
  • Three-dimensional characterisation of tumours
  • Metastatic colonisation
  • Tumour-microsystem interactions
  • Analysis of tumour vascularisation
  • Anti-tumour therapies efficacy evaluation
Cardiovascular research
  • Development of the cardiovascular system
  • Analysis of vascular architecture and remodelling
  • Study of ischaemic damage
  • Mechanisms of vascular ageing
Immunology and systems biology
  • Spatial analysis of the lymphatic system
  • Study of the body’s systemic responses to disease and treatment
  • Research into the body’s stress response
  • Systemic effects of obesity on organs and tissues
Developmental biology and morphogenesis
  • Embryogenesis
  • Morphogenesis and organogenesis
  • Developmental models and embryos
Organoids and advanced 3D models

Nanomedicine and biodistribution
  • Biodistribution of drugs, nanoparticles and nanoplastics
Plant and environmental biology
  • Plant development
  • Tissue architecture
  • Interactions between organisms and the environment
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Biodistribution of nanoparticles in the mouse lung.

Not sure whether light-sheet microscopy is right for your research?

Whether you’re working with organs, embryos, organoids or other optically transparent samples, we’d be happy to discuss your imaging options with you, help you design your experiment and support pilot measurements through the Imaging Horizon Incubator project.

Contact Tomáš Heizer, M.Eng.


 

number of views: 5 author: theiz, last modification: theiz, 23.10.2026