MPI (Bruker Biospin, Ettlingen, Germany) enables direct detection of paramagnetic nanoparticles in an oscillating magnetic field. Magnetic particle detection is a quantitative (no attenuation of the signal) tomographic 3D functional imaging technique with a high scan rate (up to 46 images/s). In combination with MRI or CT, this enables high resolution sensitive monitoring of superparamagnetic nanoparticles (SPIO, super paramagnetic iron oxide nanoparticles) that can visualize the bloodstream and to track cells or macromolecules, monitor their movements and distribution in an organism. MPI is 1.000 times faster than PET and 100 times more sensitive than MRI
Basic Technical Parameters:
Excitation (drive) field amplitude: 14 mTMagnetic field gradient: 2.5 T / m
Acquisition speed: 20 ms
Spatial resolution: max. 0.5 mm
Sensitivity: 100 pmol Fe in magnetic nanoparticles
The scanner is equipped by mouse (diameter 40 mm) and rat (diameter 60 mm) receiver coils, which increase sensitivity by up to 10 dB.
Applications:
Rapid quantitative imaging of magnetic contrast enables
· Nontoxic angiography
· Cell tracking
· Research on drug carriers
· Nano-robotics
· Cardiovascular research
· Regenerative medicine